Chemistry terminology

The following terms ate some of the most common used in combinatorial chemistry and HTS. More complete glos.saries ean be found in Beck-Sicklingcr. A., and Weber, P. Combinatorial Strategics in Biology and Chemistry. New York. John Wiley Sons, 2002, and in MacLean, D., et al. Glossary of terms used in combinatorial chemistry. J. Comb. Chem. 2 562-578, 2000. 

ADMET (also ADME, ADMET-PK) The collection of a molecule s properties related to absorption, distribution, metaho-lism, excretion, mxiciiy, and /ihormocoEnetics. These factin are being increasingly considered in combinatorial libnii) design. to yield molecules that will be more suitable as drags. 

Aptaraer RNA molecule that displays specific binding to a target, usually a protein. Aptamets arc often used in miciuar-rays in place of antibodies, to bind peptide ligands. 

Array synthesis The form of parallel synthesis in which the reaction vessels are maimained in a particular spatial arrange-mem, such as a grid in a microtiter plate. Such arrays genentted on a microscopic basis arc termed a sitatially addresstdtk library. 

Backbone A linear scaffold to which substituents are attached. Common backbones include the a carbon backbones of peptides and peptoids. 

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PHYSICAL ORGANIC CHEMISTRY TERMINOLOGY (lUPAC Recommendations)... 

NAD(P)H DEHYDROGENASE (QUINONE) PHYSICAL ORGANIC CHEMISTRY TERMINOLOGY (lUPAC Recommendations) 6-PHYTASE... 

Chemistry terminology can be somewhat confusing (what an understatement ) as electrons are transferred back and forth and you try to keep track of everything with terms like reduction, oxidizing, and the like. The phrase OIL RIG is a helpful little tool to remember what means what ... 

As an example, for styrene at 0°C. the following data are typical (30) rate of polymerization = 14.5%/hour, dose rate = 2.2 X 103 rads/hour, average DP 103. Since 1 rad corresponds to the absorption of 100 ergs/gram of material, it can be demonstrated, on the basis of the above values, that approximately 6 X 105 monomer units are incorporated into polymer for each 100 e.v. of energy absorbed. In conventional radiation chemistry terminology this would be expressed as G(.m0nomer)... 

The 2d - 3)-dimensional NHIM can be viewed as the energy surface of an (unstable) invariant subsystem which as mentioned above, in chemistry terminology, corresponds to the "activated complex," which as an oscillating "supermolecule" is located between reactants and products. 

Polymer chemistry terminology The following is a very simplified explanation. Polymers can be made up of carbon (C), hydrogen (H), chlorine (Cl), fluorine (F), oxygen (O), and nitrogen (N). These six elements, either naturally or synthetically, first form rather simple... 

Rosa Munoz Bello teaches Physics and Chemistry at the High School in Valencia. Her research interests include history of science textbooks and teaching methods in the eighteenth and nineteenth century and scientific terminology. At present, she is pursuing her (or a) Ph.D. in the Department of History of Science at the University of Valencia. Her latest article was about chemistry terminology. 

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