Chemicals Sharing the Same Principal Mode of Action

1 Chemicals Sharing the Same Principal Mode of Action 

Some of the best evidence of links between effects at different organizational levels comes from studies with OPs, where levels of AChE inhibition have been compared with associated neurophysiological and behavioral effects. In adopting this approach, however, the picture is complicated by mounting evidence for these compounds acting on target sites other than AChE, as discussed in Section 16.3. Thus, behavioral disturbances caused by an OP may be the outcome of interaction with both AChE and one or more other sites of action. The following account, however, will be concerned with situations where effects of OPs are closely related to levels of AChE inhibition. More complex scenarios will be discussed in the next section. 

In one study with common marmosets, the animals were dosed with diazinon (10, 90, or 130 mg/kg i.m.) and measnrements of erythrocyte cholinesterase inhibition 

Hart (1993) reports a study of behavioral effects of the OP insecticide chlorfenvin-phos on captive starlings (Sturnus vulgaris). Birds were dosed with 3-9 mg/kg of the insecticide presented orally in the form of capsules. Behavioral effects were related 

Organic Pollutants An Ecotoxicological Perspective, Second Edition 

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