Chemically modifying gauze

Cellulose is a major naturally occurring storage and structural polymer in plants. Cellulose and its derivatives have been widely investigated for various biomedical applications. Although pure cellulose is not readily resorbable in the body, it can be chemically modified to cause chain scission of the structure and hence be made bioresorbable. Oxidized cellulose is one such example. Surgicel is a commercial oxidized cellulose, which is available in the form of gauze pads for use as resorbable hemostatic wound dressings. 

The phenomenon under consideration was studied systematically in the beginning of the 19th century. In 1815, Davy performed experiments that dealt with catalytic combustion on platinum gauzes. The term catalysis , however, was introduced by Berzelius in 1836. He first defined a catalyst (Berzelius, 1836) as a compound, which increases the rate of a chemical reaction, but which is not consumed during the reaction. This definition was later amended by Ostwald (1853-1932) in 1895 to involve the possibility that small amounts of the catalyst are lost in the reaction or that the catalytic activity is slowly decreased A catalyst is a substance that increases the rate of approach to equilibrium of a chemical reaction without being substantially consumed in the reaction. It was more than a century after Berzelius first definition that Marcel Prettre s introduced the notion of yield The catalyst is a substance that increases the rate of a chemical transformation without modifying the yield, and that is found intact among the final products of the reaction. ... 

DeJonge Permeation Test Method (20). Wien first developed, this test method used an enclosed hood over a variable speed conveyor belt where fabric and gauze were layered and attached to wooden frames. The fabric was then passed under a nozzle which spr s the material and the gauze was later analyzed for chemical residues. This method is closer to simulating exposure under actual use conditions, and is currently being modified. 

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