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Chemical transdermal enhancers drug absorption

Mrozek et al. synthesized fourteen acyloxy derivatives of 5(S-cholic acid as novel potential transdermal penetration enhancers and intestinal drug absorption modifiers (Figure 49.6). Nontoxic bile acid/salt derivatives (as amphiphilic compounds) are used widely in drug formulations as excipients and can influence gastrointestinal solubility, absorption, and chemical/enzymatic stability of drugs. Transdermal penetration enhancers are special pharmaceutical excipients that interact with skin components to increase the penetration of drugs into blood circulation after topical application. Structure confirmation of all generated compounds was accomplished by H NMR, NMR, IR, and mass spectrometer (MS) spectroscopy. [Pg.1489]


See other pages where Chemical transdermal enhancers drug absorption is mentioned: [Pg.233]    [Pg.406]    [Pg.17]    [Pg.2741]    [Pg.3846]    [Pg.3851]    [Pg.104]    [Pg.137]    [Pg.232]    [Pg.641]    [Pg.128]    [Pg.455]    [Pg.996]    [Pg.2015]    [Pg.3846]    [Pg.87]    [Pg.140]    [Pg.1463]    [Pg.214]    [Pg.1716]   
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Absorption enhancers

Chemical enhancement

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Chemical transdermal enhancers

Drug absorption

Drug absorption enhancement

Drug absorption transdermal drugs

Enhancement drugs

Transdermal

Transdermal absorption

Transdermal drugs

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