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Chemical structure analysis toxicity studies

Molecular structural analysis is a developing method. The objective of a molecuhu structural analysis is to demonstrate a physical, structural, or chemical similarity between tlie chemical in question and a known toxic chemical tliat produces toxic and healtli effects in experimental animals and/or humans. Unfortunately, scientists do not fully understand tlie effects of slight changes in tlie chemical structure and tlieir biological effect on humans. As a result, tills type of analysis is useful in preliminary studies to identify potential health hazards for further e. amination with more established metliods in short-tenii tests or tests in experimental animals, hi its present stage of development, molecular structural analysis caiuiot be used to make absolute decisions about tlie appropriate levels of exposure of humans to chemicals... [Pg.302]

Prior to the initiation of chronic toxicity studies, there should be characterization of test chemical. Information on chemical identity and structure can sometimes be used in an analysis based on structure activity relationships to indicate biological or toxicologic activity. The physical and chemical characteristics of the test chemical provide important information for the selection of administration routes, study design, and handling and storage of the test chemical. [Pg.495]

Sakuratani Y, Sato S, Nishikawa S, Yamada J, Maekawa A, Hayashi M (2008) Category analysis of the substituted anilines studied in a 28-day repeat-dose toxicity test conducted on rats correlation between toxicity and chemical structure. SAR QSAR Environ Res 19, 681-96. [Pg.127]

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See also in sourсe #XX -- [ Pg.272 , Pg.273 , Pg.274 , Pg.275 , Pg.276 , Pg.277 ]



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