Chemical mutagenesis 42-46 literature

FIGURE 1. Projected yearly increase in chemical mutagenesis literature. The solid portion of the block represents articles presently in EMIC s data base the broken-line extension represents the approximate number of articles EMIC projects that it will accumulate. 

Source John S. Wasson, The literature of chemical mutagenesis. Mutagens Principles and Methods for Their Development, vol. Alexander Hollaender, 271-287. New York Plenum Press. In Chemical 3, edited by... 

Chemical mutagenesis, a survey of the 1971 literature (EMIC report)... 

Chemical mutagenesis A survey of the 1974/1975 literature (EMIC report) Oak Ridge, Tenn. 

An exhaustive bibliography of papers dealing with the biology and genetics of Drosophila was commenced by Muller (1939) and continued in four more volumes by Herskowitz (1952, 1958, 1963, 1969). These volumes include an author and subject and species index. Most of the technical and research notes in DIS are also indexed in these volumes, as is also much of the literature on chemical mutagenesis in Drosophila, Finally, books by Auerbach (1962) and by Loveless (1966) are useful surveys of the field of chemical mutagenesis. 

Prior to the advent of site-directed mutagenesis as a viable technique for the production of specifically modified proteins, the last major event to exert a major influence on the study of protein structure and function was the development of X-ray diffraction analysis for the detailed structural analysis of macromolecules. In the intervening thirty years, the availability of protein structures obtained in this manner combined with a wide range of physical and chemical studies of these proteins allowed development of substantial insight into the relationship between the structure of a protein and its functional attributes. There was some reason to expect, therefore, that functional characterization of specifically mutated proteins based on understanding developed with more classical techniques should permit efficient confirmation of existing hypotheses, particularly for proteins for which the available literature is as extensive as that for cytochrome c. 

Bradley, M.O., B. Bhuyon, M.O. Francis, R. Langenbach, A. Peterson, and E. Huberman. Mutagenesis by chemical agents in V79 Chinese hamster cells A review and analysis of the literature. A report of the GENE-TOX Program. Mutat. Res. 87 81-142, 1981. 

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