Chemical Labeling Methods for Protein Quantification

Schematic representations of methods for stable-isotope protein labeling for quantitative proteomics. 2003 Nature Publishing Group. 

Targeting residue Name of labeling method Isotopes Reference 

Sulfhydryl Isotope-coded affinity tagging (ICAT) D 71 

Amines Isotope-coded protein labeling (ICPL) D 90 

To overcome the problems of the original ICAT reagent, many relative methods have been developed. More isotopes, including and 0, are 

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