Chemical biology platforms establishment

Establishment of Organizational Structures for Chemical Biology Platforms... 

Before animal testing, analytical and biological assay capabilities must be developed while the NME is being scaled up to produce a sufficient quantity with acceptable purity for use in subsequent studies. Drug standards and analytical methods for evaluating the bulk NME and the final product, as well as the tentative chemical, physical, and biologic specifications, are then established. In parallel, formulation studies are initiated to produce a stable dosage form that will provide a suitable platform for delivery of the NME in a reproducible manner. 

In principle, several different systems can serve as a basis for the mentioned platforms. As shown in Fig. 1, we will discuss in this contribution a variety of complementary 2D and quasi-3D architectures. SAMs of organothiols, disulfides or sulfides on gold [29,59] and SAMs of organosilicon compounds on hydroxylated silicon surfaces [60-62] are probably among the best known model systems due to their ease of preparation and the high level of structural and chemical control. Vesicles (liposomes) [63] and substrate-supported lipid bilayers [64-67] are related well-established model systems for biological membranes that allow one to study membrane constituents in a controlled environment, and they can serve as a platform for biosensors based on naturally existing biomolecules present in a milieu that approximates a ceU mem-... 

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