Chemical biology libraries

Tietze, L.F. Lieb, M.E. (1998) Domino Reactions for Library Synthesis of Small Molecules in Combinatorial Chemistry. Current Opinion in Chemical Biology, 2, 363-371. 

Donia, M.S., Hathaway, B.J., Sudek, S. et al. (2006) Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nature Chemical Biology, 2, 729. 

Roche, O., Trube, G Zuegge, J., Pflimlin, P., Alanine, A. and Schneider, G. (2002) A virtual screening method for prediction of the HERG potassium channel liability of compound libraries. Chembiochem A European Journal of Chemical Biology, 3, 455-459. 

The PSSC concept provides a conceptually new principle to inspire compound library design for chemical biology and medicinal chemistry... 

New insights into chemical biology from g. OBFeome libraries. Curr Opin Chem Biol 12, 55-59. 

Golebiowski, A., Klopfenstein, S. R., and Portlock, D. E. (2003). Lead compounds discovered from libraries Part 2. Current Opinion in Chemical Biology 7, 308-325. 

Shelat, A. A., and Guy, R. K. (2007). The interdependence between screening methods and screening libraries. Current Opinion in Chemical Biology 11, 244-251. 

Since its introduction, this technique has gained more and more importance in the combinatorial field. The main advantage of biological libraries, in comparison to chemical libraries, depends on the possibility of increasing remarkably the number of different molecules that can be screened at the same time. Furthermore, once the phage displaying the active sequence has been selected, it is able to replicate itself by infecting host bacterial cells successive selection and amplification cycles result in an exponential enrichment of the active peptide sequence. 

Kugawa, E, Watanabe, M., and Tamanoi, F. 2007. Chemical biology/chemical genetics/chemical genomics importance of chemical library. Chem-Bio Inform. J. 7, 49-68. 

Synthesis of Chemical Genetics Libraries New Organic Synthesis Approaches to the Discovery of Biological Activity... 

In parallel, hits are nominated from the group of actives, and chemical optimization is begun, to generate optimized leads. Ideally, the biased library consists of lead-like compounds and allows an efficient, short optimization program. We can anticipate that this parallel approach in chemical biology will lead to time reduction by 3.5 years as compared to the classical linear approach. 

Combinatorial Libraries Overview of Applications in Chemical Biology Compound HandUng... 

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