Chelators Yersinia

Gehring AM, Mori I, Perry RD, Walsh CT. The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. Biochemistry 37 11637-11650, 1998. 

Higgins et al. (1999) developed a system for the detection of Staphylococcus enterotoxinB (SEB), ricin toxin. Yersinia pestisYl antigen and 5ac/7/MX anthracis PA antigen based on the principle of electrochemiluminescence (ECL). ECL is a process that involves the generation of light from a voltage-dependent, cyclic oxidation-reduction reaction of rathenium heavy metal chelate. The redox... 

Infection risk Iron is an essential nutrient in many species, and iron overload increases the risk of infections. Deferoxamine is a natural siderophore, and its use is a susceptibility factor for infections with a variety of microbes, notably Yersinia enterocolitica and Mucorales infections, and increases their infectivity. On the other hand, iron chelators, by extracting iron, may also have cm anti-infectious action, which may be therapeutically beneficial, in particular in the treatment of malaria (deferiprone) [4 ] or mucormycosis (deferasirox) [5 ]. While the use of iron-chelating drugs is currently being further investigated, for the... 

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