Cyclodextrins charged

Schulte, G., Heitmeier, S., Ghankvetadze, B., and Blaschke, G. (1998). Ghiral capillary electrophoresis-electrospray mass spectrometry coupling with charged cyclodextrin derivatives as chiral selectors. /. Chromatogr. A 800, 77—82. 

Cherkaoui, S., and Veuthey, J. L. (2001). Use of negatively charged cyclodextrins for the simultaneous enantioseparation of selected anesthetic drugs by capillary electrophoresis-mass spectrometry. /. Pharm. Biomed. Anal. TJ, 615 — 626. 

B Chankvetadze, G Endresz, G Blaschke. Charged cyclodextrin derivatives as chiral selectors in capillary electrophoresis. Chem Soc Rev 25 141-146,... 

In electrokinetic chromatography (EKC, electroosmosis, electrophoresis) the highly soluble ionic cyclodextrin-derivatives (e.g. carboxymethyl-6-cyclodextrin) are employed (47). A non-charged guest will migrate in the electric field, because it is transported by the charged cyclodextrin host. 

Add a cyclodextrin to the electrolyte [19]. The neutral cyclodextrin serves as a hydrophobic vehicle to carry hydrophobic solutes through the aqueous bulk phase. Charged cyclodextrins can also be employed in the mixed mode in conjunction with SDS [22],... 

Owens PK, Fell AF, Coleman M, Berridge JC. Method development in liquid chromatography with a charged cyclodextrin additive for chiral resolution of rac-amlodipine utilizing a central composite design. Chirality 1996 8(7) 466-476. 

Chankvetadze B, Endresz G, Blaschke G. About some aspects of the use of charged cyclodextrins for capillary electrophoresis enantio-separation. Electrophoresis 1994 15(6) 804-807. 

Despite these evident drawbacks, a broad variety of SOs have been used in CMPA-based enantiomer separations, including cyclodextrins, proteins, macro-cyclic antibiotics, chiral ion-pairing agents, amino acids in combination with transition metal salts, and crown ethers. Recent application for the separation of pharmaceutically relevant chiral compounds utilized P-cyclodextrins [46-48] charged cyclodextrins [49, 50], macrocyclic antibiotics [51, 52] and chiral ion-pairing agents [53, 54]. A more detailed discussion of CMPA-based enantiomer separation is beyond the scope of this chapter. The interested reader is referred to dedicated reviews [55, 56]. 

NJ Munro, J Palmer, AM Stalcup, JP Landers. Charged cyclodextrin-mediated sample stacking in micellar capillary electrophoresis. A simple method for enhancing the detection sensitivity of hydrophobic compounds. J Chromatogr B 731 369-381, 1999. 

Charged cyclodextrin chiral mobile phase additives for capillary electrophoresis... 

C. Garcia-Ruiz, A.L. Crego and M.L. Marina, Comparison of charged cyclodextrin derivatives for the chiral separation of atropisomeric polychlorinated biphenyls by capillary electrophoresis. Electrophoresis, 24, 2657-2664, 2003. 

Figure 4 Simultaneous chiral separation of the isomeric tripeptides Gly-a-Asp-PheNH2 and Gly- -Asp-PheNHa. Experimental conditions 40/47cm polyacrylamide-coated capillary, 50 im, 50 mmol I sodium phosphate buffer, pH 5.25, 60mgmr car-boxymethyl- -cyclodextrin, -20 kV, UV detection at 215 nm. (Reprinted with permission from Sabah S and Scriba GKE (1998) Electrophoretic stereoisomer separation of aspartyl dipeptides and tripeptides in untreated fused-siiica and polyacrylamide-coated capillaries using charged cyclodextrins. Journal of Chromatography A 822 137-145 Elsevier.)...

Sabah S, Scriba G (1998) Electrophoretic stereoisomer separation of aspartyl dipeptides and tripeptides in untreated fused-silica and polyacrylamide-coated capillaries using charged cyclodextrins. J Chromatogr A 822 137-145... 

Simonyi M. Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins. J. Pharm. Biomed. Anal. 2011 54 475 81. 

Tang W, Ng SC. Monosubstituted positively charged cyclodextrins synthesis and applications in chiral separation. J. Sep. Sci. 2008 31 3246 3256. 

KubaCak P, Mikus P, Valikova I, Havranek E. Chiral separation of alkylamine antihistamines in pharmaceuticals by capillary isotachophoresis with charged cyclodextrin. Drug Dev. Industr. Pharm. 2007 33 (11) 1199-1204. 

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