Challenges of Complexity in Chemistry and Beyond

Despite the advanced formulation that have been put forward, we must emphasize that the treatment of nonlocality in chemistry is still an open problem calling for accurate representations (i.e., beyond the simple local ansatz) for the nonlocal reactivity kernels as well as suitable approximations to the higher-order responses of the electron and/or spin density distribution. Further work of implementation and computational testing on this important topic remain a challenge in thefield of both spin-free and spin-polarized versions of conceptual DFT. As a result of the complex nature of these quantities, almost no applications of these indices in practical chemical problems have been presented yet. 

Nevertheless, no matter how fast the organic synthesis develops, there are still a lot of natural products chemists cannot conquer. The complexities of natural organisms are always beyond our imagination. The exploration of complicated natural products always challenges the wisdom and creativity of organic chemists. Furthermore, the cross fusion of various subjects in modern era put forward new requirements and challenges for chemists working in the field of total synthesis of natural products. It requires them to have not only excellent chemistry skills and visions but also open mind in the new era. It also requires chemists to be able to analyze problem in the views over various fields. 

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