Chain scission collagen

Collectively, the MMP are capable of degrading all of the major protein constituents of the extracellular matrix. The interstitial collagenases that are the focus of this review dissolve collagen fibrils by making a single scission across all three a. chains at a specific, sensitive locus of exposed type I, II... 

HFC and HNC also differ with respect to their peptide and collagen specificities. Both HFC and HNC cleave all three a chains of types I, II and III collagens following the Gly residue of the partial sequences Gly-[Ile or Leu]-[Ala or Leu] in these collagens [91,92] at a single site located approximately three-fourths from the NH2-terminus. This single scission of these... 

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