Cervical glycoproteins

Cervical glycoprotein bovine cervical 26 mucin 74 c 0.643 0.635(5) 59G1, 72G1 +1.3... 

Carlstedt, I. and Sheehan, J. K. Stmctnre and macromolecnlar properties of cervical mucus glycoproteins. Symposia of the Society for Experimental Biology 1989, 43, 289-316. 

Carlstedt, I., Lindgren, H., Sheehan, J. K., Uhnsten, V, and Wingerup, J. Isolation and characterization of human cervical-mucus glycoproteins. Biochem J. 1983, 211, 13-22. 

Van Kooj, R. J., Kathmann, H. J. M., and Kramer, M. F. Human cervical mucus and its mucous glycoprotein during the menstrual cycle. Fertility and Sterility 1980, 34, 226-233. 

Because the BBB prevents the effective accumulation of many of the antivirals, the CNS can act as a reservoir of virus. This reservoir could potentially reinfect the peripheral tissues. The CNS-to-blood movement of HTV-1 has not been investigated, but movement of two of its proteins has been. The coat glycoprotein gpl20 is cleared by non-saturable mechanisms (Cashion et al., 1999). However, it has a propensity to be reabsorbed predominately by nasal drainage. As a result, it drains by way of lymphatic vessels directly to the cervical lymphatic nodes. If whole virus also takes this route, then that means that lymph nodes could be directly reinfected without the virus having to enter the circulation where it could be exposed to antiviral agents. 

Sheehan, L Carlstedt, I. Hydrodynamic properties of human cervical mucus glycoproteins in 6M-guanidinum chloride. Biochem. J. 1984, 217, 93-101. 

Nasir-Ud-Din Jeanloz, R. Vercelotti, J. McArthur, J. Studies on bonnet monkey cervical mucus the effect of proteases on mucus glycoproteins of macaca radiata. Biochimica. Biophysica. Acta 1981, 678, 483-496. 

In a screening on the effects of poria on chemotherapy drug uptake in human cervical carcinoma cells, an aqueous extract of poria enhanced the target cell sensitivity to the p-glycoprotein (P-gp) substrate paclitaxel, with no changes in sensitivity to 5-fluorouracil, which is not a substrate for P-gp. Poria increased cellular uptake of rhodamine 123 (Takara et al. 2005). 

The extraparotid saliva of Macaque monkeys contains a glycoprotein (mol. wt. 9.6 X 10 ) capable of inhibition of the precipitation of calcium phosphate. The major glycoproteins obtained from Bonnet monkey cervical mucous of the peri-ovulatory and of the pre-menstrual phases differ mainly in the point of linkage of the terminal neuraminic acid residues and of the substitution of the... 

Products isolated chromatographically from the proteolytic digest of a glycoprotein from bovine cervical mucous contained peptide regions, together with two different sizes of glycopeptide subunit regions. ... 

The enzymic removal of sialic acid from bovine cervical mucus has been used in an attempt to establish a molecular basis for the rheological properties. The storage modulus, viscosity, and c.d. spectrum were essentially unchanged, indicating that the removal of terminal sialic acid residues does not affect the physical structure of the glycoprotein to any appreciable extent. 

A glycoprotein isolated from the cervical mucus of the bonnet monkey has Neu5Ac and Neu5Gc in a ratio of 3 1, but no 0-acetylated sialic acids (Hatcher... 

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