Cervical cancer concurrent therapy

Although flaws in these studies of hydroxyurea left their results open to question, the GOG was convinced that the weight of the evidence supported inclusion of hydroxyurea in the control arms of future trials. In the early 1980s, 308 patients with stages IIB-IVA cervical cancer were randomly assigned to receive radiation therapy with concurrent hydroxyurea or radiation therapy with concurrent misonidazole. A preliminary review... 

Eifel PJ, Winter K, Morris M et al (2004) Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer an update of Radiation Therapy Oncology Group Trial (RTOG) 90-01. J Clin Oncol 22 872-880... 

I.V. Chemotherapy Plus Radiation (Chemoradiation) In a multi-institutional study reported in 1999 by Morris et al. of MDACC, the effects of radiation therapy to the pelvic and paraaortic field were compared to that of pelvic irradiation and concurrent chemotherapy with 5FU and cisplatin in women with advanced cervical cancer. The estimated cumulative rates of survival at 5 years were 73% among patients treated with radiotherapy and chemotherapy and 58% among patients treated with radiotherapy alone. Because of the success of chemoradiation in the management... 

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