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Cerivastatin metabolism

Wang JS, Neuvonen M, Wen X, et al. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos 2002 30 1352-1356. [Pg.353]

For instance/ the interaction between cerivastatin and gemfibrozil/ which has resulted in cases of severe rhabdomyolysiS/ is likely due to the inhibition of cerivastatin metabolism by gemfibrozil (i.e./ pharmacokinetic interaction)/ in addition to the propensity of both drugs to cause skeletal muscle toxicity (i.e./ pharmacodynamic interaction) (13-15). [Pg.230]

Fluvastatin may increase warfarin toxicity because both compete with P450 2C9 for metabolism. Cerivastatin can cause fatal rhabdomyolysis risk with other statins unclear. [Pg.275]

Cerivastatin uses a secondary CYP2C8-mediated metabolic pathway, which is unaffected by itraconazole (12). The effects of itraconazole on the pharmacokinetics of cerivastatin and its major metabolites have been investigated in a randomized, double-blind, crossover study (13). Inhibition of the CYP3A4-mediated M-l pathway led to raised serum concentrations of cerivastatin, cerivastatin lactone, and metabolite M-23, resulting in increased concentrations of active HMG-CoA reductase inhibitors. However, the effect was modest. [Pg.533]

T, Cheesman MJ, Kwok PY, Marciante K, Heckbert SR, Psaty BM, Totah RA (2010) Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis. Pharmacogenet Genomics 20 619-629... [Pg.86]

Gemfibrozil increased the plasma concentration of cerivastatin, mainly caused by the inhibition of CYP2C8-mediated metabolism of cerivastatin by gemfibrozil glucuronide, which may be concentrated in hepatocytes, and partly caused by its inhibition of OATP1 Bl-mediated uptake [207, 215],... [Pg.306]

Shitara. Y.. Hirano. M.. Adachi. Y.. Itoh. T, Sato, H.. and Sugiyama. Y. (2004) fn vitro and in vivo correlation of the inhibitory effect of cyclosporin A on the transporter-mediated hepatic uptake of cerivastatin in rats. Drug Metabolism and Disposition, 32. 1468-1475. [Pg.344]


See other pages where Cerivastatin metabolism is mentioned: [Pg.300]    [Pg.554]    [Pg.305]    [Pg.330]    [Pg.223]    [Pg.535]    [Pg.300]    [Pg.554]    [Pg.305]    [Pg.330]    [Pg.223]    [Pg.535]    [Pg.259]    [Pg.272]    [Pg.346]    [Pg.358]    [Pg.358]    [Pg.68]    [Pg.272]    [Pg.318]    [Pg.323]    [Pg.113]    [Pg.170]    [Pg.199]    [Pg.232]    [Pg.291]    [Pg.295]    [Pg.295]    [Pg.296]    [Pg.345]    [Pg.554]    [Pg.555]    [Pg.564]    [Pg.691]    [Pg.148]    [Pg.533]    [Pg.533]    [Pg.243]    [Pg.256]    [Pg.95]    [Pg.484]    [Pg.76]    [Pg.282]    [Pg.326]    [Pg.381]   
See also in sourсe #XX -- [ Pg.295 , Pg.296 ]




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Cerivastatin

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