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Gemfibrozil-glucuronide

Gemfibrozil increased the plasma concentration of cerivastatin, mainly caused by the inhibition of CYP2C8-mediated metabolism of cerivastatin by gemfibrozil glucuronide, which may be concentrated in hepatocytes, and partly caused by its inhibition of OATP1 Bl-mediated uptake [207, 215],... [Pg.306]

Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Glucuronide... [Pg.280]

Gemfibrozil is absorbed quantitatively from the intestine and is tightly bound to plasma proteins. It undergoes enterohepatic circulation and readily passes the placenta. The plasma half-life is 1.5 hours. Seventy percent is eliminated through the kidneys, mostly unmodified. The liver modifies some of the drug to hydroxymethyl, carboxyl, or quinol derivatives. Fenofibrate is an isopropyl ester that is hydrolyzed completely in the intestine. Its plasma half-life is 20 hours. Sixty percent is excreted in the urine as the glucuronide, and about 25% in feces. [Pg.788]

See other pages where Gemfibrozil-glucuronide is mentioned: [Pg.113]    [Pg.170]    [Pg.232]    [Pg.244]    [Pg.286]    [Pg.287]    [Pg.294]    [Pg.296]    [Pg.296]    [Pg.533]    [Pg.534]    [Pg.305]    [Pg.306]    [Pg.85]    [Pg.294]    [Pg.62]    [Pg.225]    [Pg.280]    [Pg.113]    [Pg.170]    [Pg.232]    [Pg.244]    [Pg.286]    [Pg.287]    [Pg.294]    [Pg.296]    [Pg.296]    [Pg.533]    [Pg.534]    [Pg.305]    [Pg.306]    [Pg.85]    [Pg.294]    [Pg.62]    [Pg.225]    [Pg.280]    [Pg.190]    [Pg.206]    [Pg.206]    [Pg.207]    [Pg.207]    [Pg.224]    [Pg.358]    [Pg.625]    [Pg.309]    [Pg.323]    [Pg.74]    [Pg.85]    [Pg.122]    [Pg.128]    [Pg.199]    [Pg.200]    [Pg.291]    [Pg.295]    [Pg.297]    [Pg.297]    [Pg.298]    [Pg.345]    [Pg.345]    [Pg.541]    [Pg.555]    [Pg.564]    [Pg.691]   
See also in sourсe #XX -- [ Pg.85 ]



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Gemfibrozil

Glucuronidated

Glucuronidation

Glucuronides

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