Cerivastatin

C23H,i,FN04 124863-78-1) see Cerivastatin sodium diethyl 1,1 -(dithiodi-2,1 -elhanediyl)bis[6,8-difiuoro-l, 4-dihydro-7-(4-methyl-l-piperazinyl)-4-oxo-3-quinoline-carboxylic acid diethyl ester]... 

CjHjO., 105-45-3) see Ampicillin Cefradine Cerivastatin sodium Dicloxacillin Epicillin Felodipine Flucloxacillin Fluvastatin sodium Nifedipine Nitrendipine Sultamicillin Talampicillin... 

Fibrates are the most effective triglyceride-lowering agents and also raise HDL cholesterol levels. Combination therapy with a fibrate, particularly gemfibrozil, and a statin has been found to increase the risk for myopathy. Of the 31 rhabdomyolysis deaths reported with cerivastatin use, 12 involved concomitant gemfibrozil.25 Therefore, more frequent monitoring, thorough patient education, and consideration of factors that increase the risk as reviewed previously should be considered. 

B., Gemfibrozil/Cerivastatin Interaction, AAPS PharmSci. 2001, 3 (Suppl.), abstract No. 3566. 

Muck, W., Mai, I., Fritsche, L., Ochmann, K., Rohde, G., Unger, S., Johne, A., Bauer, S., Budde, K., Roots, I., Neumayer, H.-H., Kuhlmann, J., Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporin-treated kidney transplant recipients, Clin. Pharmacol. Ther. 1999, 65, 251— 261. 

It has been found that the 3-hydroxy-3-methylglutaryl-CoA (HMG CoA) inhibitors statins (atorvastatin, pravastatin, and cerivastatin), widely prescribed cholesterol-lowering agents, are able to inhibit phorbol ester-stimulated superoxide formation in endothelial-intact segments of the rat aorta [64] and suppress angiotensin II-mediated free radical production [65]. Delbose et al. [66] found that statins inhibited NADPH oxidase-catalyzed PMA-induced superoxide production by monocytes. It was suggested that statins can prevent or limit the involvement of superoxide in the development of atherosclerosis. It is important that statin... 

Cerivastatin sodium Bay col Cholesterol lowerers Muscle weakening 1999 u.s. 2001 2... 

Sparing, R., Sellhaus, B., Noth, J. and Block, F. (2003) Rhabdomolyse unter Cerivastatin-Monotherapie. Der Nervenarzt, 74, 167—171. 

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