Gemfibrozil cerivastatin

Pogson GW, Kindred LH, Carper BG. Rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy. Am J Cardiol 1999 83(7) 1146. 

Ozdemir O, Boran M, Gokce V, Uzun Y, Kocak B, Korkmaz S. A case with severe rhabdomyolysis and renal failure associated with cerivastatin-gemfibrozil combination therapy—a case report. Angiology 2000 51(8) 695-7. 

Roca B, Calvo B, Monferrer R. Severe rhabdomyolysis and cerivastatin-gemfibrozil combination therapy. Ann Pharmacother 2002 36 730-731. 

Fibrates are the most effective triglyceride-lowering agents and also raise HDL cholesterol levels. Combination therapy with a fibrate, particularly gemfibrozil, and a statin has been found to increase the risk for myopathy. Of the 31 rhabdomyolysis deaths reported with cerivastatin use, 12 involved concomitant gemfibrozil.25 Therefore, more frequent monitoring, thorough patient education, and consideration of factors that increase the risk as reviewed previously should be considered. 

B., Gemfibrozil/Cerivastatin Interaction, AAPS PharmSci. 2001, 3 (Suppl.), abstract No. 3566. 

Backman, J.T., Kyrklund, C., Neuvonen, M. and Neuvonen, P.J. (2002) Gemfibrozil greatly increases plasma concentrations of cerivastatin. Clinical Pharmacology and Therapeutics, 72, 685-691. 

Cerivastatin was withdrawn in 2001 after 31 people in the USA taking cerivastatin, 12 of whom had also taken gemfibrozil, died of severe rhabdomyolysis (2). 

Myalgia and a marked increase in creatine kinase was precipitated in a 74-year-old woman with normal renal function who took gemfibrozil 1200 mg/day 3 weeks after she had started to take cerivastatin 300 pg/day (10). 

The last patient fared well on a combination of gemfibrozil and cerivastatin until he received influenza vaccination. Rhabdomyolysis has been reported with various... 

Bermingham RP, Whitsitt TB, Smart ML, Nowak DP, Scalley RD. Rhabdomyolysis in a patient receiving the combination of cerivastatin and gemfibrozil. Am J Health Syst Pharm 2000 57(5) 461M. 

Alexandridis G, Pappas GA, Elisaf MS. Rhabdomyolysis due to combination therapy with cerivastatin and gemfibrozil. Am J Med 2000 109(3) 261-2. 

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