Cerebral oxygen delivery

Increased cerebral metabolism increased cerebral oxygen delivery. 

In a small comparison of ibuprofen and indometacin in preterm infants with patent ductus arteriosus there was no apparent difference in the rate of patent ductus arteriosus closure ibuprofen did not impair cerebral hemodynamics or oxygenation, while indometacin impaired cerebral oxygen delivery (4). 

Awasthi V et al (2007) Cerebral oxygen delivery by Hposome-encapsulated hemoglobin A positron-emission tomographic evaluation in a rat model of hemorrhagic shock. J Appl Physiol 103 28-38... 

S. Goldman, F. Sutter, F. Ferdinand, and C. Trace, Optimizing Intraojjerative Cerebral Oxygen Delivery Using Noninvasive Cerebral Oximetry Decreases the Incidence of Stroke for Cardiac Surreal Patients, Heart Surg. Forum, 7(5), 392 (2004). 

Figure 8 Effects of 20-mill adenosine infusion (3 (imol/kg) into an unanesthetized, nomioxic midgestation sheep fetus in utero on cerebral oxygen delivery and consumption. While oxygen delivery did not show any significant change, cerebral oxygen consumption fell. p < 0.05, paired t-test versus preinfusion level. (From Ref 161.)...

Therapeutic Hbs such as DCLHb potentially are unique hemodiluents in that in addition to reducing viscosity, cerebral ischemic injury may also be reduced by the maintenance of oxygen delivery by the tHb and by the inactivation of nitric oxide (NO). This hypothesis was supported by the results of a study of cerebral ischemic injury in rats in which the effects of DCLHb infusion were compared to those of DCLHb infusion with l-NAME (an NO synthase inhibitor) or... 

Nicardipine selectively dilates cerebral and coronary vessels. Thus, myocardial blood flow and oxygen delivery are increased, but performance is not. 

Cooper et al. in 1998 [35] performed another study on the adult brain. NIR was used to determine the effects of changes in the rate of oxygen delivery on adult rat-brain chemistry. Absolute levels of oxyhemoglobin, deoxyhemoglobin, and the redox state of the Cua center in mitochondrial cytochrome oxidase. A study on human infants was performed by Wyatt et al. [36]. They used NIR to quantify the cerebral blood volume in human infant. 

Decreased cerebral blood flow, resulting from acute arterial occlusion, reduces oxygen and glucose delivery to brain tissue with subsequent lactic acid production, blood-brain barrier breakdown, inflammation, sodium and calcium pump dysfunction, glutamate release, intracellular calcium influx, free-radical generation, and finally membrane and nucleic acid breakdown and cell death. The degree of cerebral blood flow reduction following arterial occlusion is not uniform. Tissue at the... 

Birth asphyxia (loss of fetal oxygen during delivery) accounts for only a minority of cases of cerebral palsy. 

Hutchinson PJ, Gupta AK, Fryer TF, Al-Rawi PG, Chatfield DA, Coles JP, et al. Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury a combined microdialysis and triple oxygen positron emission tomography study. J Cereb Blood Flow Metab 2002 22 735-45. 

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