Cerebral cortex, rat

Phyllis, JW, Smith-Barbour, M and O Regan, MH (1996) Changes in extracellular amino acid transmitters and purines during and following ischemias of different durations in the rat cerebral cortex. Neurochem. Int. 29 115-120. 

Moehler, H and Okada, T (1977) Properties of [3H]diazepam binding to benzodiazepine receptors in rat cerebral cortex. Life Sci. 20 2101-2110. 

Riddall DR, Leach MJ, Davison AN (1976) Neurotransmitter uptake into slices of rat cerebral cortex in vitro effect of slice size. J Neurochem 27(4) 835-839... 

The rat neostriatum receives massive input from the cerebral cortex and thalamus (Chung 1979 Kemp and Powell 1971 Somogyi et al. 1981). 

FIGURE 1. The effect of repeated systemic administration of various doses of MDMA on the content of serotonin (5-HT) and S-HIAA and the density of 5-HT uptake sites in rat frontal cerebral cortex... 

MDMA, MDMA plus 10 mg/kg citalopram, and MDMA plus 25 mg/kg SKF 525A on the density of serotonin (5-HT) uptake sites in homogenates of rat frontal cerebral cortex... 

FIGURE 5. Timecourse of recovery of (A.) serotonin (5-HT) uptake sites and (B.) 5-HT conten in rat cerebral cortex following repeated systemic administration of MDMA... 

Blue, M.E. Yagaloff, K.A. Mamounas, L.A. Hartig, P.R. and Molliver, M.E. Correspondence of 5-HT2 receptor distribution with serotonin innervation in rat cerebral cortex. Abstr Soc Neurosci 12 145, 1986. 

Mamounas. L.A. Mullen, C. and Molliver, M.E. Morphologically dissimilar serotonergic axon types in rat cerebral cortex are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Abstr Soc Neurosci 14 210, 1988. 

The collaboration between several academic laboratories has shown that the imidazole moiety on some of the earlier H3 antagonists can be replaced with a piperidine. For example, the ciproxifan analogue (16) has a pK of 8.4 in rat cerebral cortex [80]. This compound showed in vivo efficacy after p.o. administration to a mouse. Other piperidines studied by these researchers include (17) (H3 p 2 = 7.21 in guinea-pig ileum) [81] and (18) (human K[ — 2.8 nM, p 2 = 7.42 in guinea-pig ileum) [82]. The authors have also found that benzyl ethers such as (19) are somewhat weaker H3 antagonists (p 2 = 6.3 in guinea-pig ileum) [83]. 

Hollins, C. and Stone, T. W., Adenosine inhibition of aminobutyric release from slices of rat cerebral cortex, British Journal of Pharmocology, 69, 107, 1980. 

---