Cerebral cortex development hypothyroidism

Eayrs, J.T., and Horn, G., 1955, The development of cerebral cortex in hypothyroid and starved rats. Anat. Rec.. 121 53. 

Abnormalities in specific regions of the cerebral cortex and its corticospinal projections, associative cortex and myelination are likely to contribute to neurological impairments in both rats and humans afflicted with hypothyroid disorders. However, although these findings provided us with information about the role ofTH in brain development, they do not provide insight into the developmental timing of TH action on specific brain areas that may underlie the aforementioned observations in children. 

QUANTITATIVE STUDIES OF THE EFFECTS OF HYPOTHYROIDISM ON THE DEVELOPMENT OF THE CEREBRAL CORTEX... 

It is very well known for many years that neonatal hypothyroidism deranges the development of the cerebral cortex (C.C.)> producing profound and often irreparable alterations in its structure . ... 

The importance of dendritic spines in the establishment of neuronal connections, and the results obtained from the above mentioned study of the effect of darkness on the development of the mouse visual cortex, lead us to think that this mathematical model could be used, as a tool, to study the effects of hypothyroidism on the development of the cerebral cortex. 

Animal models in the marmoset and the sheep have been developed to study the effect of severe iodine deficiency on brain development. Both these models are characterised by the production of severe maternal and fetal hypothyroidism which is associated with effects on the maturation of the cerebral cortex and cerebellum. There was a reduced brain weight with a reduced number of cells as indicated by reduced DNA, a greater density of cells in the cerebral cortex and reduced cell acquisition in the cerebellum. 

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