Cerebellum lead damage

Effects of lead on the nervous system are both structural and functional, involving the cerebellum, spinal cord, and motor and sensory nerves the result may be deterioration of intellectual, sensory, neuromuscular, and psychological functions. The pathogenesis of lead-induced injury to the nervous system is poorly understood, but may be mediated through vascular damage, the direct action of lead on neurons, or alterations in porphyrin metabolism. Retarded brain growth in prenatal... 

Thus, the neuropathological studies confirm that serious, but nonspecific damage to the nervous system occurs in poisoning with organic lead compounds. The nerve cells in the hippocampus, reticular formation, and cerebellum may be particularly sensitive to Et4Pb. This is in agreement with cHnical effects upon memory, attention level, psychomotor, and EEG changes. 

Nervous System. Structural and functional nervous system effects of lead are apparent. These effects involve the brain, cerebellum, spinal cord, and motor and sensory nerves leading to specific areas of the body. Neural tissue is very sensitive to the toxic effects of lead with cases of brain swelling reported at even low lead concentrations. Severe subcellular damage is usually noted in the cerebellar cortex and cerebral cortex, and sometimes in the basal ganglia. This damage also impairs the flow of blood in the brain [25]. 

---