Cephems ceftizoxime

C24H23N3OHS) see Ceftizoxime 4-nitrobenzyl 7(i )-amino-3-cephcm-4-carboxylate (Ci4H] 3N303S 68780-69- ) see Ceftizoxime 4-nitrobenzyl 7-amino-3-chloro-3-cephem-4>carboxylate hydrochloride... 

The patient s serum was tested for antibodies against five penicillins and 30 different cephems (that is all types of cephalosporins), using protocols to detect drug adsorption as well as immune-complex mechanisms. His serum contained an IgM antibody that formed immune complexes with 10 of the 30 cephems. The 10 drugs were classified as oxime-type cephalosporins, that is they had a common structural formula at the C7 position on 7-aminocephalosporinic acid. This antibody did not show any cross-reactivity with five kinds of penicillins (ampiciUin, aspoxicillin, carbenicil-lin, piperacillin, sulbeniciUin). The authors asked a difficult question Why did anaphylactic shock accompany acute hemolysis Their answer was that the complex of ceftizoxime with IgM anti-ceftizoxime might act like anti-A or anti-B. This hypothesis will surely be further tested. In the meantime, it would be wise not to use the newer cephalosporins too freely. 

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