Ceftizoxime

Ceftizoxime (83) is structurally of interest in that it lacks any functionality at C-3 and therefore cannot undergo the usual metabolic deacetylation experienced by many cephalosporins. Its synthesis involves condensation of the acid chloride corresponding to ester 74 (74a) with 3-lactam 82. ... 

Aminocephalosporanic acid Cefazolin sodium Ceftizoxime Cephacetriie sodium Cephalogiycin Cephaloridine Cephalothin sodium Cephapirin sodium 2-Amino-5-chlorobenzonitrile Ciorazepate dipotassium 2-Amino-5-chlorobenzophenone Chlordiazepoxide HCi Pinazepam Prazepam... 

BIs-triethylammonium pyrophosphate Adenosine triphosphate Bis(trimethylsilyl) acetamide Cefaclor Cefroxadine Ceftizoxime... 

CH4N2 463-52-5) see Itraconazole formamidine hydrochloride (CH5QN2 6313-33-3) sec Allopurinol 7-formamidocephalosporanic acid (CiiHj2N20fiS 27267-35-2) see Cefamandole 2-(2-formamido-4-thiazolyl)-2-methoxyiminoacetic acid (C7H7N3O4S 83594-38-1) see Ceftizoxime (2-formamidothiazol-4-yl)oxoacetic acid (CfiH4N204S 64987-06-0) see Cetixime formic acid... 

C24H23N3OHS) see Ceftizoxime 4-nitrobenzyl 7(i )-amino-3-cephcm-4-carboxylate (Ci4H] 3N303S 68780-69- ) see Ceftizoxime 4-nitrobenzyl 7-amino-3-chloro-3-cephem-4>carboxylate hydrochloride... 

C22HHJN3O7S 53116-50-0) see Ceftizoxime 4-nitrobenzyl 3-hydroxy-7- 2-thienyIacetaniido)-3-ce-phem-4-carboxyIate... 

When used for intraabdominal infection, aminoglycosides should be combined with agents that are effective against the majority of B. fragilis. Clindamycin or metronidazole is the agent of first choice, but others, such as antianaerobic cephalosporins (e.g., cefoxitin, cefotetan, or ceftizoxime), piperacillin, mezlocillin, and combinations of extended-spectrum penicillins... 

Ciprofloxacin, levofloxacin ceftriaxone, ceftizoxime, ceftazidime, cefepime) plus metronidazole Ciprofloxacin, in Combinaion... 

Chloramphenicol may be used in place of penicillin G. Several third-generation cephalosporins (e.g., cefotaxime, ceftizoxime, ceftriaxone, and cefuroxime) approved for the treatment of meningitis are acceptable alternatives to penicillin G (Table 36-5). Meropenem and fluoroquinolones are suitable alternatives for treatment ofpenidUin-nonsusceptible meningococci. 

Third- or fourth-generation cephalosporins (cefotaxime, ceftriaxone, ceftizoxime, ceftazidime,... 

Spectinomycin 2 g IM once, or ceftizoxime 500 mg IM once, or cefotaxime 500 mg IM once, or cefoxitin 2 g IM once with probenecid I g po once, or gatifloxacin 400 mg po once, or lomefloxacin 400 mg po once, or norfloxacin 800 mg po once plus... 

Cefotaxime I gIV every 8 hours or ceftizoxime I g IV eveiy 8 hours/or ciprofloxacin 400 mg IV every 12 hours/ or ofloxacin 400 mg IV every 12 hours/ or levofloxacin 250 mg IV every 24 hours/ or spectinomycin 2 g IM every 12 hours Spectinomycin 40 mg/kg IM once (not to exceed 2 g)... 

Monotherapy with second-or third-generation cephalosporin (cefoxitin 1-2 g IV every 6 hours or ceftizoxime 1-2 g IV every 8 hours) or... 

A linear correlation was found between the absorbance and the concentration (12.5-100 mg/L) of sixteen antineoplastic nitrosoureas, belonging to 4 distinct chemical classes, in the presence of ceftizoxime (296) in acidic media (Xmax 500 nm)601. 

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