Centre for Adverse Reactions Monitoring

Most patients do not react adversely to blood products. However, some have mild to severe effects immediately or delayed for 48 hours. Information on adverse reactions to blood products collected by the New Zealand Centre for Adverse Reactions Monitoring enables the identification of unusual or unpredictable adverse reactions risk factors such as concomitant medications, underlying diseases, rate of administration and batch problems (4). 

Anonymous. Moduretic-anaphylactic shock. Uppsala WHO Collaborating Centre for Adverse Drug Reaction Monitoring, Adv React Newslett 1988 (3 ). 

One is thus looking primarily to the individual practitioner and specialist for pointers to the unexpected, irrespective of whether the element of surprise lies in the nature of the reaction, its severity, or the circumstances of its occurrence in this setting, the merest shadow of suspicion is sufficient to justify a record of the event. Such a record often need not go into print at all. If it is entrusted to an Adverse Reactions Monitoring Centre, one will very... 

There seem to be individuals with a metabolic idiosyncrasy who develop serious but probably fully reversible liver damage when exposed to ranitidine. The Netherlands Centre for Monitoring of Adverse Reactions has pubhshed data on six cases, in most of which other causal factors could be excluded (12), and a fatal case of liver injury has been reported from France (SEDA-16, 422). 

A single-centre study monitored the efficacy and safety of intralesional cidofovir administered for recalcitrant cutaneous viral warts [7 ]. Two hxmdred and eighty patients were treated with intralesional cidofovir (15mg/mL once per month). Local adverse reactions were frequent all patients reported pain and burning sensations during the injection. In 51/280 patients, local pruritus and erythema occxured after treatment. Post-inflammatory hyperpigmentation of the hands occurred in 20/280 patients. Renal function was monitored, and there were no alterations at the end of treatment, nor any systemic side effects reported. In this small, uncontrolled study, all local side effects resolved spontaneously and did not require medical intervention. 

Communication issued by the Netherlands national centre for monitoring of adverse drug reactions (1976) Agranulocytosis during treatment with aprindine. Ned. T. Ceneesk., in press. 

Netherlands Centre for Monitoring of Adverse Drug Reactions... 

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