Cellulose Ciprofloxacin

Yerri-Swamy, B. Prasad, C.V. Reedy, C.L.N. Mallikarjuma, B. Rao, K.C. Subha, M.C.S. Interpenetrating polymer network microspheres of hydroxy propyl methyl cellulose/poly(vinyl alcohol) for control release of ciprofloxacin hydrochloride. Cellulose 2011, 18 (2), 349-357. 

Bajpai AK, Mishra A (2008) Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacine an in-vitro dynamic study. J Mater Sci Mater Med 19 2121-2130... 

The determination of two fluoroquinolone antibacterials (ciprofloxacin and norfloxacin), either in pure form or in tablets, is possible on the basis of the formation of a ternary complex palladium(II)-eosin-fluoroquinolone in the presence of methyl cellulose as surfactant. The ternary complexes show an absorption maximum at 545 nm and obey Beer s law in the concentration range 3-10mgl for both quinolones. 

Cellulose Based Drug Delivery Synthetic Nanoparticles, Microsphere, Tablet Excipients, Protein Based Drug Delivery, Spray Drying Acetaminophen, Cyclosporine A, Norfloxacin, Ofloxacin, Ciprofloxacin, Gatifloxacin, Levofloxacin, Protein delivery and purification... 

Ocular systems (Figure 7.5b) with application in the lower ophthalmic conjunctival sac for the controlled release of ciprofloxacin (pre- or post-operative treatment of topical infections, as well as conjimctivitis) were obtained from polyvinyl alcohol and sodium carboxymethylcellulose linking the two polymers by an esterification reaction between the hydroxyl groups of the polyvinyl alcohol and carboxyl groups of carboxy-methyl cellulose [47]. Membranes were obtained by the incorporation of the antibiotic into the polymer solution with the addition of glycerol as a plasticizer (in order to ensure the flexibility of the membrane). The advantage of using these polymers comes from their biocompatibility and from the fact that they are water soluble as the controlled release occms, the membrane is dissolved by the tear bed at 35"C temperature. 

Semi interpenetrating polymer networks pPNs) of carboxymethyl cellulose (CMC) and polyacrylic acid were prepared by Bajpai et. al. [130] and its potential for controlled release of ciprofloxacin were assessed. The IPNs were characterized by IR spectral analysis and ESEM analysis. The entrapped drug was examined for its antibacterial activity and chemical stability. The effects of experimental parameters such as vaiying chemical composition of the IPNs, % loading of Cfe (ciprofloxacin) hydrochloride, pH, and temperature of release medium and presence of salts ions in outer solution were examined on the release profile of the drug. 

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