Cellulose carboxymethyl-, review

Follicle Stimulating Hormone (FSH, follitropin) [9002-68-0] Mr-36,000. Purified by Sephadex G100 gel filtration followed by carboxymethyl-cellulose with NH4OAC pH 5.5. The latter separates luteinising hormone from FSH. Solubility in H20 is 0.5%. It has an isoelectric point of 4.5. A soln of lmg in saline (100ml) can be kept at 60° for 0.5h. Activity is retained in a soln at pH 7-8 for 0.5h at 75°. The activity of a 50% aq EtOH soln is destroyed at 60° in 15 min. [Bloomfield et al. Biochim Biophys Acta 533 371 1978 Hartree BJ 100 754 1966 Pierce and Parsons Ann Review Biochem 50 465 1981],... 

A review of vaginal bioadhesive formulations indicates that bioadhesive tablets have been used for localized treatment of diseases in the vaginal tissue.F ° l For example. Bleomycin, an antitumor agent, was incorporated into a flat-faced disk fabricated from a combination of hydroxypropyl cellulose and poly-(acrylic acid) (Carbopol 934). ° The tablet was designed to release Bleomycin at a slow rate to minimize irritation to healthy mucosa. Another vaginal tablet is formulated from the combination of poly(acrylic acid) with hydroxypropyl methylcellulose and ethylcellu-lose. Other polymer combinations evaluated for potential bioadhesive vaginal delivery include poly(acrylic acid) and sodium carboxymethyl cellulose with Avicel PH102 (methylcellulose) as the diluent. Insulin has been formulated in a cross-linked poly(acrylic acid) gel... 

As already indicated, the number of polysaccharide derivatives reported is enormous, and indeed, many papers have been published on particular types, for example, O-(carboxymethyl) cellulose, and enzyme derivatives of polysaccharides. On such derivatives alone, reviews have been, or could be, written the present article must, therefore, of necessity be a condensed form restricted to the principal findings. Where reviews on particular derivatives have been published, this is indicated, and, generally, only subsequent papers are considered here. The reader may also find it useful to refer to other works that consider a number of derivatives of particular polysaccharides, such as cellulose, " chitin, starch, " and others. References to polysaccharide derivatives are now being reported annually in Specialist Periodical Reports. ... 

Th. Heinze and A. Koschella, Carboxymethyl ethers of cellulose and starch—A review, Macromol. Symp., 223 (2005) 13-39. 

The separation characteristics of a considerable variety of other TLC supports were also tested using different dye mixtures (magnesia, polyamide, silylated silica, octadecyl-bonded silica, carboxymethyl cellulose, zeolite, etc.) however, these supports have not been frequently applied in practical TLC of this class of compounds. Optimization procedures such as the prisma and the simplex methods have also found application in the TLC analysis of synthetic dyes. It was established that six red synthetic dyes (C.I. 15580 C.I. 15585 C.I. 15630 C.I. 15800 C.I. 15880 C.I. 15865) can be fully separated on silica high-performance TLC (HPTLC) layers in a three-solvent system calculated by the optimization models. The theoretical plate number and the consequent separation capacity of traditional TLC can be considerably enhanced by using supports of lower particle size (about 5 fim) and a narrower particle size distribution. The application of these HPTLC layers for the analysis of basic and cationic synthetic dyes has also been reviewed. The advantages of overpressured (or forced flow) TLC include improved separation efficiency, lower detection limit, and lower solvent consumption, and they have also been exploited in the analysis of synthetic dyes. 

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