Cell Signaling Network Database

Igarashi, T., and Kaminuma, T. (1997) Developing of a cell signaling networks database, Pacific Symposium on Biocomputing 97 (R. B. Altman, A. K. Dunker, L. Hunter, and T. E., Klein, eds.), pp. 187-197, World Scientific, Singapore. 

Figure 6.4. Cell signaling networks database. The cell signaling networks database (CSNDB) provides facilities for searching/retrieving transduction (signaling) pathways.

Cell Signaling Network Database (CSNDB) GPCRDB NucleaRDB Receptor database ReliBase... 

The first step in constructing a cell signaling network model is to generate an in silica interaction network. Signaling components of interest are identified, and data on binary interactions are extracted from the experimental literature. Often times, the creation of an entire interaction map for a large network is beyond the scope of one laboratory therefore, public databases have been created in which newly discovered proteins and/or protein interactions are deposited (57-63). However, often data are included from studies that cover a broad range of protein interactions, such as proteomic studies or yeast two-hybrid screens, and frequently contain many potential false positives or negatives. Thus, it becomes necessary to critically examine each reference to verify the interaction data reported, as this in silica network is the basis of further study. 

Takai-Igarashi, T., Y. Nadaoka, and T. Kaminuma, A database for cell signaling networks. J Comput Biol, 1998. 5(4) p. 747-54. 

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