Cell locomotion cytoskeleton, role

The Role of Myosins in Cell Locomotion The Role of Actin-Binding Proteins in Cell Locomotion The Transduction of Extracellular Motility Signals to the Cytoskeleton Lipid Flow and Cell Locomotion The Role of Cell Locomotion in Metastasis Intracellular Motility Microtubule-Based Intracellular Motility... 

The Locomotion of Amoeba The Locomotion of Fibroblastic Cell Types The Locomotion of Leukocytes The Behavior of Locomoting Cells The Role of the Cytoskeleton in Cell Locomotion The Microtubule-Based Cytoskeleton The Intermediate Filament-Based Cytoskeleton The Microfilament-Based Cytoskeleton The Organization of Microfilaments in Cells Microfilament Dynamics and Cell Locomotion Sites of Lamellar Protrusion May Be Determined by the Nucleation of Actin Polymerization... 

A FIGURE 19-29 Role of signal-transduction pathways in cell locomotion and the organization of the cytoskeleton. 

The cytoskeletons of other eukaryotic cells typically include both microtubules and microfilaments, which consist of long, chainlike oligomers of the proteins tubulin and actin, respectively. Bundles of microfilaments often lie just underneath the plasma membrane (fig. 17.22). They participate in processes that require changes in the shape of the cell, such as locomotion and phagocytosis. In some cells, cytoskeletal microfilaments appear to be linked indirectly through the plasma membrane to peripheral proteins on the outer surface of the cell (fig. 17.23). Among the cell surface proteins connected to this network is fibronectin, a glycoprotein believed to play a role in cell-cell interactions. The lateral diffusion of fibronectin is at least 5,000 times slower than that of freely diffusible membrane proteins. 

The inability of coronin cells to divide properly under axenic conditions points to a role of coronin in cell division and illustrates that various, probably independent, actin-based mechanisms are involved in guaranteeing proper cytokinesis. In conclusion, the defects in cell growth, locomotion and cytokinesis show that coronin is involved in more than a single function of the actin system and suggest that the protein plays a general role in the reorganization of the actin cytoskeleton. " ... 

---