Cell death catastrophic

For instance, synchronized U20S cells that received the peptides in an early G2 phase and were subjected to UV treatment (365 nm, 90 s) showed (a) an increased cell death ratio compared to controls, (b) an uncontrolled premature entry into M phase accompanied by mitotic catastrophe, and (c) a striking reduction in the stable G1 cell population, suggesting that 14-3-3 proteins normally regulate the onset and timing of mitosis in cycling cells and maintain stable interphase arrest in noncycling cells. The role of 14-3-3 proteins in... 

In order to inactivate a tumor cell, several distinct yet overlapping pathways may be activated. Besides the induction of pure apoptosis, other cell inactivation modalities, including programmed necrosis, mitotic catastrophe, senescence, or terminal differentiation, may be triggered (Belka 2006). The influence of a combined modality treatment on any of these end points has never been analyzed in greater detail thus, only very few data are available showing that the combination of paradigmatic radiation sensitizers with radiation quantitatively alters the induction of certain predefined mechanisms of cell death (Fig. 10.7). 

Apoptosis is a tightly regulated mode of cellular death that does not result in injury to neighboring cells or elicit an inflammatory response. On the other hand, necrosis is a catastrophic, unregulated mode of cell death that is followed by the invasion of inflammatory cells (1). Although apoptosis and necrosis are caused by distinct biochemical pathways, there is a great deal of experimental... 

Barbisan LF, Mello ML, Russo J, Vidal BC Apoptosis and catastrophic cell death in benzo[a]pyrene-transformed human breast epithelial eells. Mutat Res 1999, 431 133-139. 

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