Cell conjugates

Morgan MM, Labno CM, Van Seventer GA, Denny MF, Straus DB, Burkhardt JK Superantigen-induced T cell B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J Immunol 2001 167 5708-5718. 

Godoy-Ramirez K, Eranck K, Gaines H. A novel method for the simultaneous assessment of natural killer cell conjugate formation and cytotoxicity at the single-cell level by multi-parameter flow-cytometry. J Immunol Methods 2000 239 35 4. 

Moreover, aptamers have the potential to be used in the engineering of cell tissue or for self-rejuvenation. Future designs may be used for patients with internal bleeding. Imagine being able to administer an aptamer-stem cell conjugate that can flow through the blood and be delivered to the desired cells in order to replicate. Application of... 

The transferrin receptor was one of the first to be exploited for receptor-mediated gene delivery. All actively metabolising cells require iron that is internalised by the cell as a transferrin-iron complex by means of receptor mediated endocytosis. To exploit this ubiquitous and efficient transport mechanism for introducing DNA into cells, conjugates of chicken or human transferrin with polycations (polylysine or protamine) were synthesised and used to form complexes with plasmid DNA. The number of transferrin molecules attached to each polylysine molecule varies according to the molecular weight of the polymer, but is generally around 1 transferrin molecule for every 50 lysine residues. ... 

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