Cell adhesion fibrinogen

A 3D model of the fibrinogen-derived (very late antigen-4, VLA-4) inhibitor 4-[N -(2-methylphenyl)ureido]phenylacetyl-Leu-Asp-Val was derived from the X-ray structure of the related integrin-binding region of the vascular cell adhesion molecule-1 (VCAM-1). A 3D pharmacophore was generated with the program Catalyst, and a 3D search was performed in 8624 molecules from... 

Endothelial cell adhesion to surface-immobilized fibrinogen results in structural changes to the cells, including microfilament reorganization and cellular spreading. These interactions appear to be mediated by civ/33 binding to the Arg-Gly-Asp sequence in the C-terminal Act chain (Cheresh et al., 1989 Dejana et al., 1988 Francis et al., 1993 Suehiro et al., 1997). In... 

Many mediators of inflammation have been identified— cytokines IL-6, tumor necrosis factor alpha cell adhesion molecules intracellular adhesion molecule-1 (ICAM-I), P-selectin and acute phase reactants CR.R fibrinogen, serum amyloid A, and soluble CD40 (Fig. I) (3). Myeloperoxidase is an enzyme secreted from monocytes, neutrophils, and macrophages. A single measurement taken from patient with chest pain in the emergency department predicted the early risk of myocardial infarction and the risk of major cardiac of ends in the next 30 days to six months (15). 

Coulot P, Bouchara JP, Reiner G, Annaix y Planchenault C, Tronchin G, Chabasse D Specific interaction of Aspergillus fumigatus with fibrinogen and its role in cell adhesion. Infect Immun 1994 62 2169-2177. 

The fibrinogen receptor represents the best characterised member of the in-tegrin family of cell adhesion receptors, which are involved in a wide variety of cell-cell and cell-extracellular matrix interactions (reviewed in detail elsewhere) [14,26-29], The integrins consist of non-covalently associated transmembrane a and [i subunits [27], and are commonly grouped into classes defined by shared fi subunits over twenty receptors in eight classes are now known [26], Using the at fi nomenclature, the fibrinogen receptor is now... 

Fibrinogen 3-5 polystyrene silicone rubber glass platelets fibroblasts red cells adhesion and release enhanced (11) adhesion enhanced (12) adhesion prevented (13)... 

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