Cell adhesion domains

Sacca, B., Fiori, S., and Moroder, L. (2003). Studies of the local conformational properties of the cell-adhesion domain of collagen type IV in synthetic heterotri-meric peptides. Biochemistry 42, 3429-3436. 

Domains L homology domain Ig immunoglobulin-like domain SAM sterile alpha motif Cadherin cell-cell adhesion domain Explanations to some of the receptors PDCFR platelet derived growth fac-... 

Domains ECM Cell-Binding Domains Cell-Cell Adhesion Domains Cell-Directive Domains... 

Cell-Cell Adhesion Domains Cadherins (e.g., E-cadherin)... 

Historically, these peptides were identified by isolating domains ofinterest from naturally evolved proteins. The tripeptide RGD sequence (arginine-glycine—aspartic acid), a commonly used cell-adhesion domain, is a prime example of this. RGD was isolated in 1983 from the extracellular and plasma protein fibronectin and was identified as the minimal sequence necessary to promote cell-attachment properties (Pierschbacher and Ruoslahti 1984). Other commonly used domains include elastin-hke sequences, which are derived from the protein elastin found in connective tissue (Meyer and Chilkoti 2002), and recombinant-silks (Prince et al. 1995). Both of these peptide domains are used to confer their unique mechanical properties (i.e., resilience, elasticity, and strength) to the resulting biomaterial. 

Promotes fibronectin adsorption and exposure of cell-adhesive domains, allowing ceU growth... 

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