Celangulin

Wilfordin, tryptofordin and celangulin (Fig. 14) are antifeedant compounds obtained from extracts of the Celastraceae species Maytenus rigida [78], Trypterigium wilfordii [79] and Celastrus angulatus [77, 80], respectively, and as some products isolated from South American species have similar structural characteristics, they too have been assayed. 

The first scientific paper dealing with a non-alkaloid sesquiterpene polyol ester showing insect antifeedant activity was published by Wakabayashi et al. [128], who reported that celangulin (1), isolated from the ethyl ether extract of Chinese bittersweet root bark, exhibited activity against Spodoptera frugiperda (Noctuidae, Lepidoptera) larvae. Thus, addition of the compound in the diet at a concentration of 5 and 10 ppm, the average body weight of larvae was reduced to 61% and 37%, respectively. 

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