Tobramycin Ceftriaxone

Beauchamp D, Theriault G, Grenier L, Gourde P, Perron S, Bergeron Y, Fontaine L, Bergeron MG. Ceftriaxone protects against tobramycin nephrotoxicity. Antimicrob Agents Chemother 1994 38(4) 750-6. 

Concomitant administration of piperacillin and cephaloridine to rabbits resulted in a significant protective effect against cephaloridine nephrotoxicity [153]. Cephaloridine nephrotoxicity can be prevented by administration of other cephalosporins or penicdhns that produce little or no reduction of the cortical concentration of cephaloridine [154]. However, ceftriaxone protects against tobramycin nephrotoxicity by reducing the intracortical accumulation of tobramycin [155]. Combination of tobramycin with latamoxef protects the rat kidney from tobramycin nephrotoxicity, and the protective effect may be partially due to suppression of intrarenal accumulation of tobramycin by latamoxef. This suppression of nephrotoxicity is roughly dependent on the latamoxef dosage [81,156]. 

A fluoroquinolone a tetracycline gentamicin A fluoroquinolone amikacin a tetracycline trimethoprim-sulfamethoxazole cefotaxime, ceftizoxime, ceftriaxone, cefepime, or ceftazidime Gentamicin, tobramycin or amikacin trimethoprim-sulfamethoxazole ciprofloxacin, ticarcillin, mezlocillin, or piperacillin aztreonam cefotaxime ceftizoxime ceftriaxone cefepime or ceftazidime Ampicillin gentamicin, tobramycin, or amikacin carbenicillin, ticarcillin, mezlocillin, or piperacillin gentamicin, tobramycin, or amikacin amoxicillin/clavulanic acid ticarcillin/clavulanic acid piperacillin/tazobactam ampicillin/sulbactam trimethoprim-sulfamethoxazole imipenem or meropenem aztreonam a fluoroquinolone another cephalosporin... 

Noninterfering amidopyrin, aspirin, barbital, caffeine, cefmenoxime, cefotaxime, ceftizox-ime, ceftriaxone, cetazidime, diazepam, dibekacin, gentamycin, aycin, lidocaine, netilmicin, tetracaine, theophylline, tobramycin... 

Noninterfering acetaminophen, amikacin, ceftazidime, ceftriaxone, genteimicin, nafcillin, phenytoin, ticarcillin, tobramycin, vancomycin... 

Another study assessing the risk factors for nephrotoxicity with aminoglycosides (tobramycin and gentamicin) enrolled 1489 patients, 157 of whom developed clinical nephrotoxicity. Of these patients 118 had no immediately identifiable cause (such as acute renal failure) and further evaluation of other risk factors found that the concurrent use of cephalosporins (including cefazolin, cefotaxime, cefoxitin, cefamandole, ce-furoxime, ceftriaxone, and ceftazidime) significantly increased the risk of nephrotoxicity. ... 

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