Ceftizoxime pharmacokinetics

LeBel M, Paone RP, Lewis GP. Effect of probenecid on the pharmacokinetics of ceftizoxime. J Antimicrob Chemother 1983 12 147-155. 

B. Facca, B. Frame, and S. Triesenberg, Population pharmacokinetics of ceftizoxime administered by continuous infusion in clinically ill patients. Antimicrob Agents Che-mother 42 1783-1787 (1998). 

In ceftizoxime, the whole C-3 side chain has been omitted to prevent deactivation by hydrolysis. It rather resembles cefotaxime in its properties however, not being subject to metabolism, its pharmacokinetic properties are much less complex. 

---