Cefetamet

Second-generation cephalosporins—IV cefuroxime po cefaclor, cefditoren, cefprozil, cefuroxime axetil, and loracarbef. Third-generation cephalosporins—po cefdinir, cefixime, cefetamet, cefpodoxime proxetil, and ceftibuten. 

Acylation of the amine with the methoxime from aminothiazole-glyoxylate has a similar effect on broadening the antibacterial spectmm in the 3-methyl series. In this case, the amine group on the starting thiazole (21-3) is first protected by conversion to (28-2) by alkylation with thriphenylmethyl chloride. Condensation of the acid by the mixed anhydride method with 7-ADC A (26-6) leads to the corresponding amide. The trityl group is then removed to afford the antibiotic cefetamet (28-3) [34]. 

Nakashima M, Kosuge K, Ishii I, Ohtsubo M. [Influence of multiple-dose administration of cefetamet pivoxil on blood and urinary concentrations of carnitine and effects of simultaneous administration of carnitine with cefetamet pivoxil.]Jpn J Antibiot 1996 49(10) 966-79. 

Holford NH, Ambros RJ, Stoeckel K. Models for describing absorption rate and estimating extent of bioavailability application to cefetamet pivoxil.Pharmacokinet Biopharm, 1992 20 421-442. 

Blouin RA, Kneer J, Ambros RJ, Stoeckel K. Influence of antacid and ranitidine on the pharmacokinetics of oral cefetamet pivoxil. Antimicrob Agents Chemother 1990 34(9) 1744-8. 

Third-generation cephalosporins—PO cefdinir, cejvcime, cefetamet, cefpodoxime proxetil, and ceftibuten. 

Aminothiazol methyloxime acetic acid 19 (ATMAA) is commercially available as is the proprietary activated form of ATMAA known as DAMA 20. ATMAA side chain and its close relations are critically important structural features of third- and fourth-generation commercially viable cephalosporin-based antibiotics related to cefovecin, such as cefetamet pivoxil, cefpodoxime proxetil, cefuroxime axetil, cefpirome, cefotiam hexetil, cefdinir, ceftbuten, ceftiofur, and cehxime (Scheme... 

No clinically significant interactions appear to occur between an aluminium/magnesium hydroxide antacid and cefaclor AF, ce-falexin, cefetamet pivoxil, cefixime or cefprozil between Alka-Seltzer and cefixime or between ceftibuten and Mylanta. In contrast, antacids reduce the bioavailability of cefpodoxime proxetil. 

The bioavailabilities of cefadroxil, cefalexin, cefixime, cefprozil, and cefradine are not affected by food. Cefaclor may be given without regard to food but absorption of an extended-release preparation may be increased by food. The bioavailabilities of cefetamet pivoxii and cefuroxime axetil may be increased by administration with food. 

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