Cefepine dihydrochloride

Another example of a well-designed method for the quantitative XRPD determination of polymorphs was developed for the phase analysis of prazosin hydrochloride [49]. As an example of an XRPD method for the determination of solvatomorphs, during the quantitation of cefepine dihydrochloride dihydrate in bulk samples of cefepine dihydrochloride monohydrate, a limit of detection of 0.75% w/w and a limit of quantitation of 2.5% w/w were associated with a working range of 2.5-15% w/w [50],... 

In addition to the XRPD quantitation of cefepine dihydrochloride dihydrate in samples of cefepine dihydrochloride monohydrate, diffuse reflectance infrared spectroscopy was used to determine the solvatomorphic composition.24 For the IR assay, a working range of 1.0-8.0% w/w, with a detection limit of 0.3% and a quantitation limit of 1.0%, and these analytical limits were superior to those obtained using the quantitative XRPD method. The validity of both assay methods were limited for samples having a particle size range of 125-590 pm. 

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