CDKs CDK2/4 cyclin

Regulated Synthesis of CDKs and Cyclins The third mechanism for changing CDK activity is regulation of the rate of synthesis of cyclin or CDK or both. For example, cyclin D, cyclin E, CDK2, and CDK4 are synthesized only when a specific transcription factor, E2F, is present in... 

Moore, J. D., Yang, J., Truant, R., Kornblnth, S. (1999). Nnclear import of CDK/cyclin complexes identification of distinct mechanisms for import of CDK2/cyclin E and CDC2/cyclin Bl. The Journal of Cell Biology, 144, 213—224. 

From a dynamic point of view, we may thus see the cell cycle as driven by two self-sustained, limit cycle oscillators, one involving cdc2, and the other cdk2. The mechanism of oscillations in each case would be similar to the one described above, and would involve a cyclin and its associated cyclin-dependent kinase (cdk) and cyclin protease, as well as... 

Othet cyclins and CDKs are involved in different aspects of cell cycle progression (Table 36-7). Cychn E and CDK2 form a complex in late Gl. Cychn E is tapidly degraded, and the released CDK2 then fotms a complex with cyclin A. This sequence is necessaty fot the initiation of DNA synthesis in S phase. A complex between cychn B and CDKl is tate-hmiting fot the G2/M transition in eukatyotic cells. 

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