Cdc42 GTPase

Olson, M.E, Ashworth,A. HaU,A. An essential role for Rho,Rac and Cdc42 GTPases in cell cycle progression through Gl (1995) Science 269, 1270-1272... 

There is no doubt that each of these multiple actions is important and of great interest, but I had to make a quite arbitrary choice in selecting for discussion only one of the many functions of monomeric G proteins in the control of fundamental cellular processes. I have chosen the role of the Rho/Rac/Cdc42 GTPases in the regulation of cell proliferation, mainly because it gave me an opportunity to introduce cell-cell interactions and the role of the cytoskeleton. 

Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995 81 53-62. Nobes CD, Hall A. Rho, rac and cdc42 GTPases regulators of actin structures, cell adhesion and motility. Biochem. Soc. Trans. 1995 23 456-459. 

Edwards DC, Sanders LC, Bokoch GM, Gill GN. Activation of LIM-kinase by Pakl couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell. Biol. 1999 1 253-259. Stanyon CA, Bernard O. LIM-kinasel. Int. J. Biochem. Cell. Biol. 1999 31 389-394. 

NOBES CD, HALL A (1995) Rho, rac and cdc42 GTPases regulators of actin structures, cell adhesion and motility. Biochemical ciety Transactions, 23,456-459. 

---