CD44-mediated endocytosis

Jiang, H., R.S. Peterson, W. Wang, E. Bartnik, C.B. Knudson, and W. Knudson. 2002. A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly, and receptor-mediated endocytosis in COS-7 cells. Journal of Biological Chemistry 277(12) 10531-10538. 

De novo synthesized HA may be secreted from the cell and subsequently interact with different cell surface receptors, such as CD44, the receptor for HA-mediated motility (RHAMM), the HA receptor for endocytosis (HARE) and many others. It has become evident that these processes mediate at least three different, very important physiological processes signal transduction, formation of pericellular coats, and the receptor-mediated internalization. 

It has been determined that some cells begin to aggregate after addition of hyaluronan. The observation of aggregation was the first indication that the polysaccharide macromolecule can be bound with the cell surface. At the present time, several protein receptors, which specifically bind biopolymers on the surface of the cytoplasmic membrane, have been isolated. These have a high affinity to the HA receptors CD44 and the receptor for HA-mediated motility (RHAMM) [123]. Another receptor for hyaluronan endocytosis was found on the membrane of the endothelial cells of the liver sinus. It differs significantly from other... 

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