Cathepsin homologues

The N-terminal sequence of one peptide from the 35 kDa zone of H-gal-GP showed some homology to cathepsin B-like cysteine proteases. Molecular cloning has also identified a thrombospondin homologue associated with the diffusely staining region between zones A and B, a galectin associated with zone D (Newlands et al., 1999) and a low molecular weight (approximately 13 kDa) cysteine protease inhibitor, cystatin. 

Lycopersicon esculentum (tomato) (Solanaceae) Jasmonic acid-inducible potato API homologue Cathepsin D [123, 1241... 

Solatium tuberosum (Solanaceae) [tuber] Potato Cysteine Protease Inhibitors (PCPIs) (20-25 kDa Kunitz PI homologues - for details see Table 12 ) Cysteine proteases (e.g. Papain, Cathepsins B, H L) - for details see Table 12 [185- 188]... 

Solatium tuberosum (potato) (Solanaceae) Other PCPIs (Kunitz PI homologues cf PCPI 8.3) -PCPI 3, PCPI 5, pTl, PKI-2 (PCPI subclass I), PCPI 7, PCPI 8, PCPI 10 (PCPI subclass II) ( 20-25 kDa) Cathepsin B [100 nM], Cathepsin L [0.4 nM [186]... 

Inhibitor (PCPI) (20 kDa) (Solanaceae) [tuber] homologue) - lysosomal cathepsin L (70pM)... 

More detailed studies of epimerization in the azepanone series indicated that these compounds were configurationally stable over a pharmaceutically relevant time-scale [19]. Structure-activity relationships developed in previous series were applied successfully to the azepanone scaffold, yielding extremely potent enzyme inhibitors that exhibited good diastereomeric selectivity as well as reasonable selectivity versus cathepsin K homologues. 

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