Cataract glucocorticoids inhaled

In a population-based cross-sectional study of vision and common eye diseases in 3654 people, 49-97 years of age, inhaled glucocorticoid use was reported by 370 subjects, of whom 164 reported current use and 206 previous use. Subjects who reported using inhaled glucocorticoids had a higher prevalence of nuclear cataracts (OR = 1.5 Cl = 1.2, 1.9) and posterior subcapsular cataracts (OR = 1.9 Cl = 1.3, 2.8). The highest prevalence (27%) was in patients whose lifetime dose was more than 2000 mg (relative prevalence 5.5) (SEDA-22,187). 

In 3677 patients undergoing cataract extraction over 2 years compared with a matched control group of 21 868 people, the patients were more likely to undergo cataract extraction if they had used inhaled glucocorticoids for more than 3 years (OR = 3.06 Cl = 1.53, 6.13). This risk was not significant in patients who used low to medium doses (1000 micrograms/day or less) when the OR was 1.63 (Cl = 0.85, 3.13) after 2 years. The OR was higher in... 

Horses appear to be more sensitive to the adrenosuppressive effects of aerosolized corticosteroids than human patients. Documentation of systemic absorption (adrenal suppression) of inhaled beclometasone and fluticasone raises concerns that other systemic glucocorticoid effects may occur following aerosol administration of corticosteroids. The administration of adrenosuppressive doses (>1600 p,g/day) of beclometasone dipropionate to asthmatic human patients does not produce the other systemic side-effects of glucocorticoid administration, including a roimd face (Cushingoid facies), polyuria, polydipsia, hyperglycemia, obesity, altered carbohydrate metabolism, osteoporosis, abortion, posterior subcapsular cataract and aseptic necrosis of the... 

In a follow-up study of 232 patients from the Childhood Asthma Management Program (CAMP), a randomized, placebo-controlled comparison of budesonide and nedocromil, long-term use of inhaled glucocorticoids in the recommended dose ranges, in combination with occasional bursts of prednisone, was not associated with an increased risk of cataracts, with a median follow-up of 12 years [8 ]. 

Sensory systems Vision In a systematic review of four case-control studies in nearly 200 000 patients, there was a significant relation between cataracts and the dose of inhaled glucocorticoid the random-effects pooled odds ratio for the risk of cataracts per 1000 micrograms increase in daily beclomethasone dipropionate dose was 1.25... 

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