Catalysts for enantioselective synthesis

Hoveyda, A. H. Diversity-Based Identification of Efficient Homochiral Organometallic Catalysts for Enantioselective Synthesis. In Handbook of Combinatorial Chemistry, Nicolaou, K. C., Hanko, R., Hartwig, W., Eds. Wiley-VCH Weinheim, Germany, 2002, Vol. 2, pp 991-1016. 

Specific Brpnsted acid catalysis is a popular field within the domain of asymmetric organocatalysis. Since the introduction of stronger chiral Brpnsted acids as powerful catalysts for enantioselective synthesis in 2004, numerous asymmetric Brpnsted acid-catalyzed transformations have been developed. 

Diversity-Based Approaches to the Discovery of Catalysts for Enantioselective Synthesis... 

For a more in depth discussion, see Hoveyda AH (2002) Diversity-based identification of efficient homochiral organometallic catalysts for enantioselective synthesis. In Nicolaou KC, Hanko R, Hartwig W (eds) Handbook of combinatorial chemistry. Wiley-VCH, New York, Chap 33, p 991... 

A. H. Hoveyda, Chiral Zirconium Catalysts for Enantioselective Synthesis, in Titanium and Zirconium in Organic Synthesis (Ed. I. Marek, Wiley-VCH, Weinheim, 2002, pp. 180-229). 

We have found that chiral boronate complexes with BLA (Brpnsted acid-assisted chiral Lewis acids) to give new catalysts for enantioselective synthesis which achieve selectivity by a double effect of intramolecular hydrogen-bonding interaction and attractive ji-ti donor-acceptor interaction in the transition state by a hydroxy aromatic group [27a],... 

This article provides a brief overview of the recently developed diversity-based approaches in the screening and identification of effective metal-based chiral catalysts for enantioselective synthesis. This first wave of reports indicates... 

Until fairly recently, primarily transition metal complexes and enzymes were utilized as catalysts for enantioselective synthesis [17]. Nicolaou and Sorensen wrote the following statement in their book published in 1996 [18] In a catalytic asymmetric reaction, a small amount of an enantiomerically pure catalyst, either an enzyme or a synthetic, soluble transition metal complex, is used to produce large quantities of an optically active compound from a precursor that may be chiral or achiral. ... 

Hoveyda. Amir, H. Diversity-Based Identification of Efficient Homochiral Organometallic Catalysts for Enantioselective Synthesis. In... 

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