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Cassane skeleton

Schaller, F. Rahalison, L. Islam, N. Potterat, O. Hostettmann, K. Stoeckli-Evans, H. Mavi, S. A new potent antifungal quinone methide diterpene with a cassane skeleton from Bobgunnia madagascariensis. Helv. Chim. Acta 2000, 83, 407-413. [Pg.289]

Cassanes.— -Caesalpin (41), from Caesalpinia pulcherrima, possesses the cassane skeleton, and is thus related to the bitter principles isolated from the seeds of Caesalpinia bonducella. Cassminic acid is a minor constituent of the bark of Erythrophleum guineense. Spectroscopic measurements and an interrelationship with cassane-16,19-dioic acid have established " it as 6-oxo-7-hydroxycass-13-ene-16,19-dioic acid. N.m.r. measurements and bromination-dehydrobromina-tion studies are in accord with the axial 14a-configuration now accepted for the cassamic acid diterpenes. [Pg.133]

Examples of diterpenes with the cleistanthane and cassane skeleton have been isolated from an unidentified sterile coprophilous fungus. Sonomolide A and B (162, 163) display antifungal activity against Aspergillus fumigatus and Candida albicans but do not show antibacterial activity towards Bacillus subtilis [229]. [Pg.237]

Cassane is the basic skeleton of cassaic acid, the parent diterpenoid of alkaloids from the bark of Erythrophleum guinese and other Erythrophleum species (Fa-baceae). These act as local anaesthetics, cardiotonics, antihypertonics, and also induce cardiac arrest. Erythrophleum alkaloids such as cassaidine, cassain and cassamine are 2-(iV,iV-dimethylamino)ethyl esters of cassaic acid derivatives. [Pg.59]

The information available at this point does not provide evidence for the methyl group at C-10 and one of those at C-4. The carbon skeleton in cassanic acid was established by the transformation of vouacapenic acid (III) to compound IV and ultimate conversion to cassanic acid... [Pg.289]


See other pages where Cassane skeleton is mentioned: [Pg.202]    [Pg.202]    [Pg.4]    [Pg.17]    [Pg.141]    [Pg.388]   
See also in sourсe #XX -- [ Pg.19 , Pg.395 ]




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