Casein kinases signaling

Dejmek, J., Safholm, A., Kamp Nielsen, C., Andersson, T. and Leandersson, K., 2006, Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase lalpha signaling in human mammary epithelial cells. Mol Cell Biol 26, 6024-36. 

Kafadar KA, Zhu H, Snyder M, Cyert MS. Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I. Genes Dev 2003 17 2698-2708. 

DARPP-32 is also phosphorylated on Ser-137 and on Ser-102 (and perhaps Ser-45) by casein kinase 1 and 2 (CK1 and CK2), respectively (Girault et al., 1989, 1990b Desdouits et al., 1995b). The phosphorylation of DARPP-32 on these Ser residues has no influence on the activity of PKA or PP-1. However, by different mechanisms, phosphorylation by CK1 and CK2 enhances the phosphorylation of DARPP-32 on Thr-34 residue (Girault et al., 1989 Desdouits et al., 1995a) and therefore increases the PKA/DARPP-32-dependent signaling stimulated by D1 receptors. 

Two studies indicate that cell signaling controls HOX-specific regulation by affecting the activation/repression balance. The influence of casein kinase II (CKII) on ANTP activity may be at the level of transcriptional activation, since CKII... 

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