Casein kinase 1 binding partner

Q331S6] 2) Casein kinase-1 binding partner (CK1 BP) 3) Stem cell factor apoptosis response protein-1 (SCF ARP1), isoform a (55861) [15881]... 

Dysbindin-2B has been identified as both stem cell factor apoptosis response protein 1 (SCF ARP1) by Lucas et al. (2005) and as a casein kinase 1 binding partner (CK1BP) by Yin et al. (2006). SCF ARP1 is expressed in bone marrow-derived myelomonocytic stem cells upon induction of apoptosis by withdrawal of stem cell growth factor SCF (Lucas et al., 2005). Programmed cell death via apoptosis controls stem cell numbers during hematopoietic cell development (Domen 2001). Since apoptosis is similarly important in development of neurons (Kuan et al., 2000 Buss and Oppenheim, 2004), dysbindin-2B may play a role in nervous system development (see also Section 2.2.33.1). 

Further discussion of the dysbindin family is limited to dysbindin-1 since little is known about other family members apart from the fact that dysbindin-2B is a casein kinase 1 binding partner and a stem cell factor apoptosis response protein. In contrast, much has been learned about dysbindin-1 since its discovery was reported by Benson et al. (2001). It is the only member of the dysbindin family known to exist in invertebrates, specifically the fruit fly, and may thus date back 600 million years. Unlike all other dysbindin paralogs, it contains a coiled coil domain (CCD) allowing extensive interactions with other proteins. A leucine zipper motif in the CCD changed in the course of evolution in a manner permitting more durable interactions with binding partners. 

Yin H, Laguna KA, Li G, Kuret J. 2006. Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. Biochemistry 45 5297-308. 

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