Cascade Processes Initiated by Conjugate Addition via H-bonding Activation

4 Cascade Processes Initiated by Conjugate Addition via H-bonding Activation 

The activation of the Michael aeeeptor by the formation of an H-bonded network with the catalyst has also been applied to several very effieient easeade processes, after incorporating a suitable eleetrophile to the reaetion medium 

1 Michael/Henry and Michael/Aza-Henry Cascade Reactions 

Highly substituted cyclohexanes and cyclopentanes have been prepared by means of a cascade process involving the use of a nitroalkene as Michael acceptor and an a-substituted p-ketoester incorporating a lateral p-substituent with a terminal methyl ketone moiety at the convenient position, ready to 

On the other hand, a triple Michael/Michael/Aldol cascade sequence has been developed for the synthesis of highly substituted cyclohexanes starting from dimethylmalonate, an a,p-unsaturated aldehyde and a nitroalkene in which H-bonding catalysis and iminium activation were jointly employed for the simultaneous activation of the two Michael acceptors involved in the 

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