Cascade Processes Involving CM

Since olefin metathesis reactions involve aUcenes both as starting materials and products, they are potential candidates for cascade processes. 

Parrain and coworkers described an efficient cascade involving the ring opening of cyclopropene ketal of type 71 followed by CM with a variety of alkenes in the presence of catalyst [Ru]-I for the synthesis of protected divinyl ketones [42]. This sequence was employed by Kozmin and coworkers for the preparation of the linear center portion of bistramide A, a marine metabolite isolated from Lissodinum bistratum which exhibits potent cytotoxicity against several cell lines [43], as well as 

Hoveyda and coworkers also employed this sequence of reactions for the synthesis of the antimycobacterial agent erogorgiaene [54]. The stepwise operation was efficient but the yield for the one-pot operation was never over 20%. 

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